Function of DNA polymerase - 500 Words

Function: of DNA polymerase DNA polymerase is a very important enzyme when it comes to DNA replication. DNA polymerase, more specifically, is involved in the process of reading and adding nucleotides to the DNA strand so a complimentary stand can be made. During the DNA replication process DNA polymerase puts new nucleotides on the 3’ end of the DNA Strand. Not only does DNA polymerase add nucleotides to a DNA strand it can also act somewhat as a â€Å"proof reader†. It can pause the replication process to fix mistakes that can occur during DNA replication. Once the sequencing mistake is identified DNA polymerase can get rid of the nucleotides and continue on with the replication process. DNA polymerase functions in many different processes†¦show more content†¦They found that the type of DNA polymerase in E.coli, DNA Polymerase III, has different characteristics in the nucleus that makes its catalyzing action nonexistent. In the experiment they tried to reintr oduce the nuclease from other bacteria into the E.coli. The results show that E.coli has evolved differently than other bacteria and may use a different process to proof reading DNA, but the PHP does play a role in the structure and activity of DNA polymerase III (Barros, Guenther, Kelch, Anaya, Prabhakar, ODonnell Lamers, 2013). A structural role for the PHP domain in E. coli DNA polymerase III. BMC Structural Biology, 13(1), 1-12. doi:10.1186/1472-6807-13-8. DNA polymerase can have a particular function when it comes do different diseases or conditions. DNA polymerase has a specific function in the treatment of hepatitis B. The hepatitis B virus depends on a type of DNA polymerase called reverse transcriptase. When patients that are given a class of medication called analogue nucleosides. This medication specifically targets the DNA polymerase in the Hepatitis B Virus. In some Hepatitis B cases the DNA polymerase mutates in the presence of the treatment casing a resistance (Ngu yen, Garcia, Trinh, Nguyen, Nguyen, Nguyen, Levitt, 2009). It also can be seen in research to try to stop cancerous growth. DNAShow MoreRelatedExploring Protein Structure With The Molecular Visualization Firstglance1041 Words   |  5 Pagesusing the FirstGlance in Jmol molecular visualization to examine key structural features of proteins. This work is important because protein structure can be related to function, multiple-sequence alignments and evolutionary preservation, and designing drug. FirstGlance in Jmol makes it fairly easy to perceive structure-function relationships in the protein you chose. Using FirstGlance, it is easy to visualize and distinguish chains, and disulfide bonds are obvious. Alpha helices and beta strandsRead MoreDna Protein Protein Structure1707 Words   |  7 PagesDNA Polymerase Proteins are arguably the most structurally and functionally complex structures known to man. Through evolution spanning billions of years, these macromolecules have been perfected to perform many functions necessary for life. Proteins contain four distinct levels of structure and are composed of simple organic compounds known as amino acids. (Alberts, Bruce et al 2000) Amino acids are joined together by peptide bonds made during protein biosynthesis, and the linked amino acid chainRead MoreWhat Does It Mean For Dna Replication?991 Words   |  4 Pagesdoes it mean for DNA replication to be semi- conservative? Semiconservative replication means during DNA replication each DNA strand is used to make new template of DNA from the 2 parental strands of DNA (Thompson, Part 1: DNA Replication, 2014). 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